Clubs will instead name a 21-man squad instead of 19 in 2020 as part of revisions to the squad declaration system.
The changes have been maned in response to feedback from all sections of the game, including supporters and the media.
And for each player from outside that 21 who is then called into a 17-player match-day squad, that team will lose one of the eight interchanges permitted.
The changes apply to all fixtures in the Super League, Championship, League 1, the Coral Challenge Cup and 1895 Cup.
The only exceptions to this will involve the dual-registration system.
If a player on dual-reg is recalled by their parent club after the partner club has named a 21-player squad, they can be replaced in the 21 without the partner club losing an interchange.
And in the unusual situation of a club losing a player at a tribunal hearing after the squad declaration deadline, they can also be replaced without sanction.
In other exceptional circumstances, a club would need to seek and receive consent from the RFL Board.
The change was discussed by the RFL’s Laws Committee, which includes representatives from all sections of the professional game, at their last meeting of 2019, leading to further consultation with clubs and head coaches – and is confirmed in the Operational Rules for the 2020 season which have been circulated to clubs this week.
Karen Moorhouse, the RFL’s Chief Regulatory Officer, said: “The annual redrafting of the Operational Rules is a consultative process, as always designed to serve the good of the game as a whole, and of clubs and players in particular.
“The change to the Squad Declaration system was proposed in response to feedback from various sections of the game, including supporters and the media. As with all the other changes, we will monitor the impact of the changes carefully through the 2020 season. We are grateful to all who have contributed to this process.”